如何让我的输出像这样：“素数: 499,497...2”

import math

def is_prime(n):
    if n <= 1:
        return False
    for i in range(2, int(math.sqrt(n)) + 1):
        if n % i == 0:
            return False
    return True

def generate_prime_numbers(start, end):
    prime_numbers = []
    for num in range(start, end + 1):
        if is_prime(num):
            prime_numbers.append(num)
    return prime_numbers

start = 2
end = 499
prime_numbers = generate_prime_numbers(start, end)

output = "素数: " + ", ".join(str(num) for num in prime_numbers[::-1])
print(output)