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    多账号管理和一个账号管理多个网站的网站后台管理SaaS系统在腾讯云服务器部署教程

    多站点CMS网站内容管理后台可以管理多个网站,由于客户有多个公司,开发多个网站,可是按照传统CMS管理系统只能是一个后台管理一个网站,而且还需要独立部署;对开发和维护也麻烦,用户后期管理网站也麻烦(需要管理对个后台账号密码)。还有很多后台是php开发的,政府性网站经常遭到同行攻击,主要还是和php不可编译有关。所以综合以上种种,结合Go和PHP各自优点开发一套CMS内容管理后台,支持多个企业账号、多个站点、在线编辑网站,无需每次建站都部署,一次部署即可一直新增网站和开客户账号即可(不再像以前一个家一家单独部署),目前CMS已经用于实际企业网站管理,并在维护中比以前要省心,一套系统要做运行正常,所有网站都正常,您可以根据需要二次开发,例如:域名到期提醒,SSL证书到期提醒,用户维护未到期提醒等等。

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    NC文章详解 | 鼠成纤维细胞单细胞分析发现成纤维细胞在心肌细胞成熟中起关键作用

    Cardiac maturation lays the foundation for postnatal heart development and disease, yet little is known about the contributions of the microenvironment to cardiomyocyte maturation. By integrating single-cell RNA-sequencing data of mouse hearts at multiple postnatal stages, we construct cellular interactomes and regulatory signaling networks. Here we report switching of fibroblast subtypes from a neonatal to adult state and this drives cardiomyocyte maturation. Molecular and functional maturation of neonatal mouse cardiomyocytes and human embryonic stem cell-derived cardiomyocytes are considerably enhanced upon co-culture with corresponding adult cardiac fibroblasts. Further, single-cell analysis of in vivo and in vitro cardiomyocyte maturation trajectories identify highly conserved signaling pathways, pharmacological targeting of which substantially delays cardiomyocyte maturation in postnatal hearts, and markedly enhances cardiomyocyte proliferation and improves cardiac function in infarcted hearts. Together, we identify cardiac fibroblasts as a key constituent in the microenvironment promoting cardiomyocyte maturation, providing insights into how the manipulation of cardiomyocyte maturity may impact on disease development and regeneration.

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