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瞄准SARS-CoV‑2主蛋白:一项成功的故事,基于计算的药物重定位方法

今天为大家介绍的是来自Giosuè Costa团队的一篇论文。SARS-CoV-2主蛋白(Mpro)是病毒复制的关键酶,被认为是治疗COVID-19的有吸引力的药物靶点。在这项研究中,将虚拟筛选技术和体外实验相结合,从大约8000种FDA批准的药物中筛选出了新型Mpro抑制剂。对接分析突出显示了17个有前景的最佳候选药物,从生物学角度对它们的Mpro抑制活性进行了表征。其中,有7种头孢菌素和口服抗凝药贝曲沙班能够在微摩尔范围内阻断酶活性,且在测试的最高浓度下没有细胞毒性影响。在评估与研究配体结合相关的Mpro残基的保守程度后,评估了这些配体对SARS-CoV-2复制的影响。贝曲沙班影响SARS-CoV-2复制的能力,与其抗血栓作用相关,可能为其在治疗住院COVID-19患者中的可能应用铺平了道路。

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CentOS6.3 x86_64位安装xfce4桌面vncserver服务

CentOS6.3 x86_64位安装xfce4桌面vncserver服务 注意这里用的是最小化安装纯净系统212个包CentOS-6.3-x86_64-minimal.iso 1,wget http://mirrors.sohu.com/fedora-epel//6/x86_64/epel-release-6-7.noarch.rpm    rpm -ivh epel-release-6-7.noarch.rpm 其目的是生产epel的yum源文件 # ls CentOS-Base.repo  CentOS-Base.repo.bak  CentOS-Debuginfo.repo  CentOS-Media.repo  CentOS-Vault.repo  epel.repo  epel-testing.repo 2,# yum groupinfo xfce Loaded plugins: fastestmirror, presto Setting up Group Process Loading mirror speeds from cached hostfile  * epel: kartolo.sby.datautama.net.id epel/group_gz                                                                                                                         | 229 kB     00:05     Group: Xfce  Description: 一个能在低端机器上良好运行的轻便桌面环境。  Mandatory Packages:    Thunar    xfce-utils    xfce4-panel    xfce4-session    xfce4-settings    xfconf    xfdesktop    xfwm4  Default Packages:    NetworkManager-gnome    Terminal    gdm    leafpad    openssh-askpass    orage    polkit-gnome    thunar-archive-plugin    thunar-volman    tumbler    xfce4-appfinder    xfce4-icon-theme    xfce4-mixer    xfce4-power-manager    xfce4-session-engines    xfwm4-theme-nodoka  Optional Packages:    xfwm4-themes  Conditional Packages:    pinentry-gtk 3,# yum -y groupinstall xfce 又安装了226个包,比系统212个还多 Installed:   NetworkManager-gnome.x86_64 1:0.8.1-33.el6          Terminal.x86_64 0:0.4.7-1.el6                       Thunar.x86_64 0:1.3.0-4.el6                         gdm.x86_64 1:2.30.4-33.el6_2                        leafpad.x86_64 0:0.8.18.1-1.el6                     openssh-askpass.x86_64 0:5.3p1-81.el6               orage.x86_64 0:4.8.1-3.el6                          pinentry-gtk.x86_64 0:0.7.6-6.el6                   polkit-gnome.x86_64 0:0.96-3.el6                    thunar-archive-plugin.x86_64 0:0.3.0-2.el6          thunar-volman.x86_64 0:0.6.0-2.el6                  tumbler.x86_64 0:0.1.21-1.el6                       xfce-utils.x86_64 0:4.8.3-1.el6                     xfce4-appfinde

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177本Python最新版国外电子书分享(上)

http://file.allitebooks.com/20180817/Python For Dummies.pdf http://file.allitebooks.com/20180805/MySQL ConnectorPython Revealed.pdf http://file.allitebooks.com/20180722/Learn Raspberry Pi Programming with Python, 2nd Edition.pdf http://file.allitebooks.com/20180719/Instant Pygame for Python Game Development How-to.pdf http://file.allitebooks.com/20180623/Python Graphics.pdf http://file.allitebooks.com/20180603/Web Scraping with Python, 2nd Edition.pdf http://file.allitebooks.com/20180526/Advanced Data Analytics Using Python.pdf http://file.allitebooks.com/20180513/The Python 3 Standard Library by Example.pdf http://file.allitebooks.com/20180512/Data Science Fundamentals for Python and MongoDB.pdf http://file.allitebooks.com/20180312/Dive into Python 3.pdf http://file.allitebooks.com/20180228/Practical Python AI Projects.pdf http://file.allitebooks.com/20180223/Learn Data Analysis with Python.pdf http://file.allitebooks.com/20180218/Beginning Programming with Python For Dummies, 2nd Edition.pdf http://file.allitebooks.com/20180109/Python for the Busy Java Developer.pdf http://file.allitebooks.com/20171221/Practical Machine Learning with Python.pdf http://file.allitebooks.com/20171213/wxPython Recipes.pdf http://file.allitebooks.com/20171126/MicroPython for the Internet of Things.pdf http://file.allitebooks.com/20171124/Make Your Own Python Text Adventure.pdf http://file.allitebooks.com/20171108/Getting Started with Python and Raspberry Pi.pdf http://file.allitebooks.com/20171029/Python Machine Learning Case Studies.pdf http://file.allitebooks.com/20171009/Python for Data Analysis, 2nd Edition.pdf http://file.allitebooks.com/20171009/Programming with MicroPython.pdf http://file.allitebooks.com/20170831/Thoughtful Machine Learning with Python.pdf http://file.allitebooks.com/20170822/Test-Driven Development with Python, 2nd Edition.pdf http://file.allitebooks.com/20170813/Python Requests Essentials.pdf http://file.allitebooks.com/20170710/Effective Python Penetration

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